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because a great door for effective work has opened to me, even though many oppose me.

For a great door and effectual is opened unto me, and [there are] many adversaries.

θύρα γάρ μοι ἀνέῳγε μεγάλη καὶ ἐνεργής, καὶ ἀντικείμενοι πολλοί.